The manor house, which was built between 1896 and 1898 in the neo-Renaissance style, is located in the middle of an extensive estate.
The manor of Groß Lüsewitz was first mentioned in a document in 1344. From 1896 to 1898, the present manor house was built on the site of a baroque predecessor building, which was destroyed by fire in 1895. The architect of the new manor house was Gotthilf Ludwig Möckel, the builder was Friedrich Ferdinand Biermann, who received the estate from his father, Gottlieb Friedrich Ferdinand Biermann, who had owned the estate since 1880. After Friedrich Ferdinand Biermann's death, his son Werner inherited the estate. From 1926 to 1943, the estate was owned by Hans Thyssen from Mühlheim, followed by Eberhard Thyssen in the last two years of the war. After the expropriation of the last owner, the estate was owned by the state of Mecklenburg. The manor house was used as a TB hospital until 1949. In GDR times, the Groß Lüsewitz estate was well known for the Institute for Plant Breeding located there. A landscaped park adjoins the manor house, which was extended after 1970 to include a riding arena. The manor house has been privately owned since 2013, but is open for certain events such as Monument Day in September.
